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	anaplastic large cell lymphoma

Disease ID	1411
Disease	anaplastic large cell lymphoma
Definition	A systemic, large-cell, non-Hodgkin, malignant lymphoma characterized by cells with pleomorphic appearance and expressing the CD30 ANTIGEN. These so-called "hallmark" cells have lobulated and indented nuclei. This lymphoma is often mistaken for metastatic carcinoma and MALIGNANT HISTIOCYTOSIS.
Synonym	(ki-1+) lymphoma alcl anaplastic large cell lymphoma (alcl) cd30+ anaplastic large cell lymphoma, cd30+ anaplastic large cell lymphoma, t cell and null cell type anaplastic large cell lymphoma, t cell and null cell type (morphologic abnormality) anaplastic large-cell lymphoma anaplastic large-cell lymphomas cd 030 positive anaplastic large cell lymphoma cd30 positive anaplastic large cell lymphoma cd30+ anaplastic large cell lymphoma cd30+ anaplastic large-cell lymphoma cd30-positive anaplastic large-cell lymphoma ki 1 lymphoma ki-1 lymphoma ki-1 lymphomas ki-1+ alcl ki-1+ anaplastic large cell lymphoma large cell (ki-1+) lymphoma large cell (ki-1+) lymphoma [obs] large cell anaplastic lymphoma large cell anaplastic lymphoma (disorder) large-cell lymphoma, anaplastic large-cell lymphomas, anaplastic lymphoma large cell ki 01 lymphoma, anaplastic large cell lymphoma, anaplastic large-cell lymphoma, ki-1 lymphoma, large-cell, anaplastic lymphoma, large-cell, anaplastic [disease/finding] lymphoma, large-cell, ki-1 lymphomas, anaplastic large-cell lymphomas, ki-1 systemic anaplastic large cell lymphoma systemic anaplastic large-cell lymphoma
Orphanet	ORPHANET:98841
DOID	DOID:0050744
UMLS	C0206180
MeSH	D017728
SNOMED-CT	SNOMEDCT_US_2016_09_01:277637000
Comorbidity	UMLS \| Disease \| Sentences' Count(Total Sentences:29) C0024299 \| lymphoma \| 14 C0024291 \| hemophagocytic lymphohistiocytosis \| 3 C0024291 \| hemophagocytic syndrome \| 2 C0023448 \| lymphocytic leukemia \| 2 C0023434 \| chronic lymphocytic leukemia \| 2 C0026986 \| myelodysplastic syndrome \| 2 C0011603 \| dermatitis \| 2 C0007570 \| celiac disease \| 1 C0079731 \| b-cell lymphoma \| 1 C0085113 \| neurofibromatosis \| 1 C0004623 \| bacterial infection \| 1 C0013990 \| emphysema \| 1 C0026986 \| myelodysplastic syndromes \| 1 C0079419 \| li-fraumeni syndrome \| 1 C0030805 \| pemphigoid \| 1 C0024314 \| lymphoproliferative disease \| 1 C0030805 \| bullous pemphigoid \| 1 C0027121 \| myositis \| 1 C0003873 \| rheumatoid arthritis \| 1 C0343084 \| capillary leak syndrome \| 1 C0553662 \| juvenile arthritis \| 1 C0553662 \| juvenile idiopathic arthritis \| 1 C0206141 \| hypereosinophilic syndrome \| 1 C0002173 \| follicular mucinosis \| 1 C0004096 \| asthma \| 1 C0011615 \| atopic dermatitis \| 1 C0024299 \| lymphomas \| 1 C0011608 \| dermatitis herpetiformis \| 1 C0079731 \| b-cell lymphomas \| 1
Curated Gene	Entrez_id \| Symbol \| Resource(Total Genes:4) 6774 \| STAT3 \| CTD_human 7291 \| TWIST1 \| CTD_human 238 \| ALK \| CTD_human;UNIPROT 3320 \| HSP90AA1 \| CTD_human
Inferring Gene	(Waiting for update.)
Text Mined Gene	Entrez_id \| Symbol \| Score \| Resource(Total Genes:91) 238 \| ALK \| 7.866 \| DISEASES 896 \| CCND3 \| 2.829 \| DISEASES 8812 \| CCNK \| 1.413 \| DISEASES 1232 \| CCR3 \| 1.448 \| DISEASES 1235 \| CCR6 \| 1.118 \| DISEASES 1237 \| CCR8 \| 1.349 \| DISEASES 9332 \| CD163 \| 1.895 \| DISEASES 930 \| CD19 \| 2.007 \| DISEASES 914 \| CD2 \| 3.486 \| DISEASES 29126 \| CD274 \| 1.45 \| DISEASES 958 \| CD40 \| 1.26 \| DISEASES 921 \| CD5 \| 3.486 \| DISEASES 1043 \| CD52 \| 1.025 \| DISEASES 11190 \| CEP250 \| 2.189 \| DISEASES 8218 \| CLTCL1 \| 2.409 \| DISEASES 163882 \| CNST \| 1.084 \| DISEASES 1373 \| CPS1 \| 1.25 \| DISEASES 1378 \| CR1 \| 1.816 \| DISEASES 1380 \| CR2 \| 2.314 \| DISEASES 1447 \| CSN2 \| 1.025 \| DISEASES 1456 \| CSNK1G3 \| 2.34 \| DISEASES 4283 \| CXCL9 \| 1.002 \| DISEASES 2833 \| CXCR3 \| 2.444 \| DISEASES 9267 \| CYTH1 \| 1.47 \| DISEASES 1663 \| DDX11 \| 1.212 \| DISEASES 1791 \| DNTT \| 1.944 \| DISEASES 56940 \| DUSP22 \| 4.063 \| DISEASES 1937 \| EEF1G \| 1.497 \| DISEASES 27436 \| EML4 \| 3.371 \| DISEASES 2053 \| EPHX2 \| 2.109 \| DISEASES 355 \| FAS \| 1.972 \| DISEASES 6624 \| FSCN1 \| 2.621 \| DISEASES 2526 \| FUT4 \| 4.675 \| DISEASES 2782 \| GNB1 \| 1.468 \| DISEASES 51696 \| HECA \| 1.091 \| DISEASES 3200 \| HOXA3 \| 1.312 \| DISEASES 3320 \| HSP90AA1 \| 1.896 \| DISEASES 219844 \| HYLS1 \| 2.479 \| DISEASES 22807 \| IKZF2 \| 1.554 \| DISEASES 50616 \| IL22 \| 1.333 \| DISEASES 3662 \| IRF4 \| 2.921 \| DISEASES 3664 \| IRF6 \| 2.421 \| DISEASES 3702 \| ITK \| 2.018 \| DISEASES 3718 \| JAK3 \| 3.112 \| DISEASES 3725 \| JUN \| 1.983 \| DISEASES 3932 \| LCK \| 1.393 \| DISEASES 93273 \| LEMD1 \| 1.54 \| DISEASES 100507254 \| LINC01013 \| 3.188 \| DISEASES 4170 \| MCL1 \| 1.982 \| DISEASES 4291 \| MLF1 \| 2.76 \| DISEASES 4311 \| MME \| 2.428 \| DISEASES 4478 \| MSN \| 1.797 \| DISEASES 2475 \| MTOR \| 1.25 \| DISEASES 4580 \| MTX1 \| 2.509 \| DISEASES 345778 \| MTX3 \| 2.861 \| DISEASES 4609 \| MYC \| 2.24 \| DISEASES 55967 \| NDUFA12 \| 1.896 \| DISEASES 4772 \| NFATC1 \| 1.081 \| DISEASES 4791 \| NFKB2 \| 1.266 \| DISEASES 4857 \| NOVA1 \| 1.16 \| DISEASES 5079 \| PAX5 \| 4.076 \| DISEASES 5111 \| PCNA \| 1.612 \| DISEASES 9260 \| PDLIM7 \| 2.329 \| DISEASES 5406 \| PNLIP \| 1.987 \| DISEASES 5452 \| POU2F2 \| 1.425 \| DISEASES 639 \| PRDM1 \| 1.219 \| DISEASES 5788 \| PTPRC \| 4.562 \| DISEASES 5905 \| RANGAP1 \| 1.185 \| DISEASES 8635 \| RNASET2 \| 1.433 \| DISEASES 57674 \| RNF213 \| 2.212 \| DISEASES 6098 \| ROS1 \| 1.364 \| DISEASES 5272 \| SERPINB9 \| 2.488 \| DISEASES 8631 \| SKAP1 \| 1.76 \| DISEASES 23583 \| SMUG1 \| 1.487 \| DISEASES 692111 \| SNORD71 \| 2.631 \| DISEASES 9021 \| SOCS3 \| 1.105 \| DISEASES 6693 \| SPN \| 4.463 \| DISEASES 6776 \| STAT5A \| 1.442 \| DISEASES 6850 \| SYK \| 1.131 \| DISEASES 7037 \| TFRC \| 1.192 \| DISEASES 7072 \| TIA1 \| 4.542 \| DISEASES 7124 \| TNF \| 1.18 \| DISEASES 7127 \| TNFAIP2 \| 1.014 \| DISEASES 7293 \| TNFRSF4 \| 2.217 \| DISEASES 7170 \| TPM3 \| 4.091 \| DISEASES 7171 \| TPM4 \| 3.63 \| DISEASES 7185 \| TRAF1 \| 3.446 \| DISEASES 7187 \| TRAF3 \| 1.017 \| DISEASES 7409 \| VAV1 \| 1.873 \| DISEASES 29068 \| ZBTB44 \| 2.815 \| DISEASES 51530 \| ZC3HC1 \| 1.296 \| DISEASES
Locus	(Waiting for update.)

Disease ID	1411
Disease	anaplastic large cell lymphoma
Integrated Phenotype	(Waiting for update.)
Text Mined Phenotype	HPO \| Name \| Sentences' Count(Total Phenotypes:23) HP:0002665 \| Lymphoma \| 14 HP:0002664 \| Neoplasia \| 5 HP:0002863 \| Myelodysplastic syndrome \| 2 HP:0005550 \| Chronic lymphatic leukemia \| 2 HP:0002326 \| TIA \| 1 HP:0001370 \| Rheumatoid arthritis \| 1 HP:0012156 \| Hemophagocytosis \| 1 HP:0012190 \| T cell lymphoma \| 1 HP:0001482 \| Subcutaneous nodule \| 1 HP:0002608 \| Celiac disease \| 1 HP:0002835 \| Aspiration \| 1 HP:0002181 \| Cerebral edema \| 1 HP:0030731 \| Carcinoma \| 1 HP:0002099 \| Asthma \| 1 HP:0005200 \| Retroperitoneal fibrosis \| 1 HP:0001067 \| Neurofibromas \| 1 HP:0012191 \| B-cell lymphoma \| 1 HP:0100806 \| Sepsis \| 1 HP:0005681 \| Juvenile idiopathic arthritis \| 1 HP:0001047 \| Atopic dermatitis \| 1 HP:0000713 \| Agitation \| 1 HP:0002097 \| Pulmonary emphysema \| 1 HP:0100614 \| Muscle inflammation \| 1

Disease ID	1411
Disease	anaplastic large cell lymphoma
Manually Symptom	UMLS \| Name(Total Manually Symptoms:5) C1608408 \| malignant transformation C1282609 \| granulocytosis C0302314 \| xanthelasma C0029132 \| optic neuropathy C0010823 \| cytomegalovirus infection
Text Mined Symptom	(Waiting for update.)

Manually Genotype(Total Text Mining Genotypes:0)
(Waiting for update.)

Text Mining Genotype(Total Genotypes:0)
(Waiting for update.)

All Snps(Total Genotypes:0)
(Waiting for update.)

GWASdb Annotation(Total Genotypes:0)
(Waiting for update.)

GWASdb Snp Trait(Total Genotypes:0)
(Waiting for update.)

Mapped by lexical matching(Total Items:0)
(Waiting for update.)

Mapped by homologous gene(Total Items:0)
(Waiting for update.)

Disease ID	1411
Disease	anaplastic large cell lymphoma
Case	(Waiting for update.)

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